Инноваци - Шинэ Санаа, Шинэ Нээлт, 2014, 12(8-1)
In vitro and in vivo study of spent brewer’s yeast hydrolysate
( Судалгааны өгүүлэл )
1-Chemistry, Institute of Chemical Technology, 2-Monos group, Institute of Pharmacology
Spent brewer’s yeast Saccharomyces cerevisiae was hydrolysed using bovine pancreatic tissue as an enzyme source. The resulting hydrolysate contains 4.7% amino nitrogen
and the ratio Namin/Ntot was determined as 0.6. Moreover, other physico-chemical parameters of the hydrolysate were also comparable with the same products on foreign
markets. Toxicity of hydrolysate is low (LD50 2,5 g/kg), microbiological and heavy metal contamination were in required range. The IC50 value of obtained yeast hydrolysate’s
antioxidative activity according to the DPPH assay was 1.6±0.5 mg/ml, while IC¬50 of the yeast hydrolysate rich in Cyclo-His-Pro evaluated as 1.9 mg/mL.
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