1School of Traditional Medicine, Health Sciences University of Mongolia
2Traditional Medical ScienceTechnology and Production Corporation of Mongolia
Diet is one of four treatment methods of Traditional Mongolian Medicine (TMM) and it plays an important role in prevention and treatment of diseases. Traditional principles of disease treatment and prevention with diet can be combined with conventional medical practices and may lead to a possibility of developing new treatment and preventive strategies. In this study, the effect of horse meat which has a hot quality and goat meat which has a cold quality were examined on acute pulmonary edema induced by adrenalin hydrochloride in mice in the spring and autumn. Mice were given 2.85 g/kg of horse or goat meat for 14 days in the spring and autumn. Then acute pulmonary edema was induced in mice by injecting adrenaline hydrochloride at a concentration of 25 mg/kg. Euphillin (2.1 mg/kg) was used as a standard medicine for comparison. After administration of adrenalin hydrochloride, mice were sacrificed and lung tissues were removed for measurements of pulmonary surfactant stability coefficient, pulmonary index, and alveolar diameter. Histological analysis of the lung tissues were also performed.
Horse meat increased pulmonary surfactant stability coefficient and alveolar diameter in mice given adrenalin hydrochloride in both seasons. Horse meat had no significant effects on pulmonary index in the autumn, though it reduced it in the spring. Furthermore, histological analysis revealed that horse meat reduced pulmonary edema and improved the repair of alveolar structure in both seasons. However, goat meat had no effect on pulmonary surfactant stability coefficient and alveolar diameter in mice administered adrenalin hydrochloride in the autumn however, it increased in the spring. When compared to goat meat, horse meat decreases alveolar collapse and pulmonary edema in mice model of pulmonary edema induced by adrenalin hydrochloride.
2. Darammaaramba Luvsanchoidog. Altan Khadmal. Khukh Khot:People Printing Committee; 1984. p.693 (In Mongolian).
3. Ganbayar Ya, Tumurbaatar N. Theoretical basis of Traditional Mongolian Medicine. Ulaanbaatar:Bit service; 2003.p.24-26,43 (In Mongolian).
4. Jigmed B. Theoretical basis of Traditional Mongolian Medicine. Khukh Khot:People Printing Committee;1984.p.169 (In Mongolian).
5. Khusekhui. Summary of food theraphy. Ulaanbaatar:Erkhes printing;2005.p.106 (In Mongolian).
6. Batchimeg U. Study on basic principles of disease diagnosis, treatment, and prevention in traditional medicine. Doctor’s thesis, Ulaanbaatar:National Medical University of Mongolia; 2003. p.65 (In Mongolian).
7. Pattle RE, Properties, function and origin of the alveolar lining layer, Nature.1955;175:1125.
8. Bradbury P, Rae K. Connective tissue and stains. In Bancroft J, Stevens A, eds. Theory and practice of histological techniques. 4th ed, New York: Churchill Livingstone;1996.113-39.
9. Ambaga M, Sarantsetseg B, Bold Sh. Basis of oriental philosophy, knowledge, and science. Ulaanbaatar:Mongolian National University;1996. p.96 (In Mongolian).
10. Rubenfeld GD, Herridge MS. Epidemiology and Outcomes of Acute Lung Injury. Chest. 2007;131:554-562.
11. Somer N, Dietrich A, Schermuly R.T, Chofrani H.A, et all. Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms. Eur Resp Journal. 2008;32:1639-1651.
12. Matthay MA, Lee J. Beta 2 adrenergic agonist therapy may enhance alveolar epithelial repair in patients with acute lung injury. Thorax. 2008;63:189-190.