1School of Biomedicine, Health Sciences University, Mongolia
2 Shastin Memorial Hospital,Mongolia
3National Yang-Min University, Taiwan
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The inflammatory process plays a key role in coronary artery disease initiation, progression, and complication. The inflammatory response in large vessels involves the up-regulation of vascular adhesion molecules such as vascular cell adhesion molecule (VCAM)-l and E-selectinand inflammatory cytokines such as TNF, IL-1, or IL-6. A healthy endothelium plays a core role in cardiovascular control. Besides its regulatory functions on vasomotor tone and blood flow, endothelial NO is known to inhibit the platelet activation and modulate migration and growth of the vascular smooth muscle. Unfortunately, none of related studies has been done in Mongolia at the molecular level. Thus, the main goal of this study was to determine the prevalence and means of risk factors for CAD in Mongolia. 60 patients with macroangiopathy and 60 healthy controls were enrolled in the study. Serum mean NO values were (17.2±9.8) uM in the CAD patients and (19.6± 12) |.iM in the healthy controls without any statistical significance. In addition, serum NOx levels was not associated with presence of plaques (r=^-0.111), but significantly correlated with soluble VCAM-1 (r=-0.384) and triglyceride level (r=0.544). Levels of sVCAM-1 showed a strong correlation with IL-1. In summary, among Mongols, pathogenesis of atherosclerosis is might be mostly explained by inflammation mechanisms in addition to traditional risk factors such as age, family history of CAD, gender and dyslipidemia.
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