School of Pharmacy, Health Sciences University of Mongolia
Өгүүллийн PDF-ийг татах
O. myriophylla and O. pseudoglandulosa are the most popular components of many traditional prescriptions and named as "tag-sha" in Mongolian traditional medicine. The goal of this research was to isolate and elucidate the structures of the secondary metabolites of above two Oxytropis species and to carry out some pharmacological activity test of the extracts of these plants and develop the new preparation. Chemical constituents of the aerial part of O. myriophylla and O. pseudoglandulosa grown in Mongolia were studied. As a result of the investigation 19 compounds were isolated. 10 compounds were isolated from the aerial part of O. myriophylla and 5 of them were alkaloids, 3 were flavonoids and 2 of them were aromatic acids. N-trans-cinnamoyl-b-hydroxy-b-phenylethylamine was found to be novel natural compound and its structure has been elucidated. Absolute configuration of N-benzoyl-b-hydroxy-b-phenylethylamine was determined for the first time as 7S. The others were found for the first time from this species and alkaloid components of this species were studied for the first time too. 9 compounds were isolated from the aerial part of O. pseudoglandulosa. 3 of them are belonged to alkaloid and 6 of them are belonged to flavonoid. N-benzoyl-b-phenylefhylamine, N-trans-cinnamoyl-b-hydroxy-b-phenylethylamine, pinocembrin, 7-hydroxyflavanone, 7-methoxyflavanone, 5-hydroxy-7methoxy-flavon, robinin were isolated from this plant for the first time. The technology of producing the preparation "Ortudent" from O. myriophylla worked out.
