Монголын Анагаахын Сэтгүүлүүдийн Холбоо (МАСХ)
Mongolian Journal of Health Sciences, 2005, 2(1)
Carotid atherosclerosis is associated with Circulating Adhesion Molecules ICAM-1, VCAM-1 in CAPD Patients
( Судалгааны өгүүлэл )

Nansalmaa Erdenekhuu1, Hyun Jin Kim2, Soo Yuong Yoon2, Beom Seok Kim2, Ho Yung Lee2, Dae Suk Han2

1School of Biomedicine, Health Sciences University of Mongolia
2 Department of Internal Medicine, College of Medicine, Yonsei University., Seoul.Korea
 
Абстракт
Chronic renal failure (CRF) patients are at high risk for coronary heart disease incidence and twenty fold high risk for death compare to an age-matched general population. Recently emerging evidence suggests that endothelial adhesion molecules may participate in atherogenesis. Therefore, We investigated the association of carotid-artery intima-media thickness with the incidence of atherosclerotic cardiovascular disease in CRF patients receiving chronic peritoneal dialysis, also aimed to find potential relationship
between VC AM-1, ICAM-1 soluble adhesion molecules and carotid-artery intima-media. Atherosclerotic development was assessed by measuring intima-media thickness (IMT) and plaque prevalence of the carotid arteries using an ultrasound scanner. Serum levels of the circulating adhesion molecules ICAM- 1 and VCAM-1 were measured by an enzyme-linked immunosorbent assay (ELISA) using commercially available standard kits. IMT significantly associated with sCAM-1 (r=0.412, p=0.003), sVCAM-1 (r=0.086,
p=0.486), and strongly correlated with age (r=0.432, p<0.001). Also, CAPD duration and CRP were shown considerable positive correlation (r=0.301, p=0.032; r=0.301, p=0.032) with IMT. Multivariate and logistic analysis showed that age and sICAM-1 levels were a strong independent correlate to IMT (p<0.0003). In CAPD patients, carotid atherosclerosis is associated with inflammation and circulating levels of soluble adhesion molecules ICAM-1 and VCAM-1 and the measurement of serum adhesion
molecules, especially ICAM-1 could be best indicators for early detection of atherosclerotic vascular complications in CAPD patients. Thus, by monitoring the level of ICAM we might be able to prevent from development of cardiovascular complication or suspend the atherosclerotic process, providing us prophylactic and therapeutic opportunities for CRF patients.
 


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