¹Traditional Medical Science Technology & Production Corporation of Mongolia

²Health Sciences University of Mongolia

Cell-surface polysaccharide chains are known to contribute to cell migration, and proliferation, but their roles in anti-inflammatory and anti-ulceration activity have not been revealed earlier. We investigated topical application on inflammation and ulceration, using "Wjstar" rats. In accordance with the reduced leukocyte infiltration, exudation levels'" rats, were observed. Mononuclear cells recruitment at inflammation sites was also impaired in ihis rats. Rats showed significant delayedanti-ulcer activity with reduced re-epitheliali/ation.and angiogenesis. compared with the control rat. This study demonstrates a suitable model using rats for investigating the molecular mechanisms of protective lining (mucosa, submucosa). the first report showing that polysaccharide chains have a strong regeneration of mucous epithelium. The effect of polysaccharide preparation lo improve surface regeneration related defends on the functional group in its content such as monomers with uronic acid, and xylose and protein molecules.

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