¹Буриадын Улсын Их Сургууль, ²Уламжлалт Анагаахын Шинжлэх Ухаан Технологи Үйлдвэрлэлийн Корпораци, Улаанбаатар,

³Оросын Шинжлэх ухааны Академийн Сибирийн салбар, Ерөнхий ба Сорилын Биологийн хүрээлэн, Улаан-Үд

 

Background: For nowadays, the special attention is paid to the problem of human

adaptation in industrial countries, where people are subjected to bad ecology and

other technological and stress factors. The present work was aimed to investigate

hepatoprotective activity of adaptogenic preparations of natural origin – apilac,

Polyphytoton and Adapton-6. Apilac is a product of beekeeping and prepared

from royal jelly bees. Polyphytoton and Adapton-6 are the multicomponent herbal

adaptogenic remedies in the form of the alcohol tincture consists of 17 species

herbal plants and the dry extracts of 6 species plants.

Objectives: The aim of our study was to investigate the influence of adaptogens

apilac, Polyphytoton and Adapton-6 on liver function of laboratory animals in

acute toxicity induced by carbon tetrachloride and to compare its effect with

hepatoprotective drug Allohol.

Methods: The hepatoprotective effect was studied further in white rats of

Wistar line of both sexes weighing 160-200 g. The acute toxic liver damage was

caused by the subcutaneous injection of 50% oil solution of carbon tetrachloride

(СС14), volume of 0,4 ml/100g of animal weight once in a day during 3 days. The

experimental treatment was performed once per day, starting from the third day for

21 days after carbon tetrachloride intoxication. The effect of studied preparations

was evaluated on 7, 14 and 21 day of a study, using the blood biochemical analysis,

activity of free radical oxidation processes and antioxidant system condition. The

level of aspartate and alanine aminotransferases, cholesterol, alkaline phosphatase,

bilirubin, protein, malondialdehyde (MDA) and catalase activity in serum of rats

were determined.

Results: The use of apilac (400 mg/kg), Polyphytoton (3,0 ml/kg) and

Adapton-6 (100 mg/kg) produce the early decrease of liver function parameters,

which proves its therapeutic effect. The investigated preparations have good

pharmacotherapeutic effect, normalizes the lipid, carbohydrate metabolism, have

a membrane-stabilizing antioxidant effect, control the serum cytoplasmic enzymes,

prevent from damages of hepatocytes.

Conclusion: The use of adaptogenic preparations with hepatoprotective effect

largely contributes to the accelerated recovery of various functions of the body, in

particular antitoxic liver function.

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