Монголын Уламжлалт Анагаах Ухаан, 2013, 2(2)
Харханд үүсгэсэн панкреатитын эмгэг загварт Жамц-4 тангийн үзүүлсэн нөлөө
( Судалгааны өгүүлэл )
1Эрүүл Мэндийн Шинжлэх Ухааны Их Сургууль, 2Уламжлалт Анагаахын Шинжлэх Ухаан Технологи Үйлдвэрлэлийн Корпораци
Абстракт
Background: To study the effects of Jamts-4 tan in an experimental pancreatitis model
in rats.
Methods: Acute pancreatitis was induced in four groups of rats (n = 10) by L-arginine
20% solution (450 mg x100g, intraperitoneal single injected) and 3 days later, they received
a single oral dose of Jamts-4 tan (140 mg/kg), Pancreatin (100 mg/kg) and vehicle (distilled
water). A saline (0.9% NaCl) treated group served as a normal control. Efficacy was assessed
by the determination of serum levels of amylase and glucose.
Results: Jamts-4 tan treatments significantly (P < 0.009) attenuated the L-arginineinduced
increases in pancreatic wet weight/body weight ratio, and decreased the serum
levels of amylase as compared to the vehicle control.
Conclusion: Jamts-4 tan has the potential to combat acute pancreatitis.
Нийтлэлийн нээгдсэн тоо: 2
