1ЭМШУИС, Уламжлалт Анагаахын Сургууль, 2ЭМШУИС-Дорноговь салбар сургууль, 3ЭМШУИС, Анагаах Ухааны Сургууль
Background: Fracture healing starts with a hematoma, continues with bone formation, and ends with bone remodeling. We decided to investigate the effects of Jonsh-5 composition on the serum level of TGF-β1 during fracture healing. A Wistar rats were utilized. K-wire was inserted into the femur in a retrograde fashion, and a mid-diaphyseal closed transverse fracture was created using method of Bonnarens & Einhorn (1984).
Methods: All rats were randomly in three groups. Group 1 (Control group, n=26) was given normal food without any medicine. Group 2, 3 ( each group n=26) were administered 0.625 mg calcium supplement and 1.3 g Jonsh-5 composition with normal food. Serum analysis, histological evaluations were performed at days 1, 7, 14 and 28 and after femur fracture according to the criteria proposed by Huo et al.
Results: Serum analysis, there was significant difference treatment effect between Group 3 (Jonsh-5 composition) and Groups 1, 2 at days 3, 7, 14 and 28 days after fracture.
The histological results demonstrated a significant stimulation of the fracture healing due to group 3 compared to group 1, 2 at days 14 and 28.
Conclustion: Under studied conditions this investigation shows that administration of Jonsh-5 accelerate fracture healing process in rat femur.
