Most ot the drugs wich used for the treatment of renal disease our country is imported and items of drugs from plants are limited.
Our country is rich on medicinal plants and there is enough resourses for preparation of drug formulations.
Bergenia crassifolia is a medicinal plant used for the treatment of disease of renal and urinary tract in traditional medicine.
Bergenia crassifolia is a plant of family Saxifragaceae.
Purpose of the study was the investigation of process preparation of drug formulation from Bergenia crassofolia and their quality assessment.
Were determined technological parameters of raw material of Bergenia crassifolia.
The optimization of extraction process and the effectiveness evaluation of preparation from Bergenia crassifolia were stadied. Many extraction methods were used and choosed from them the repercolation USP method as a best.
Pharmacological investigation was carried out by determination of diuretic effect and toxicity. The maximum of diuretic activity was best in the dose of 0,3%. The toxicity was determined in the mouse and the minimum dose wich was shown toxic effect was 1,25 g/kg.
Pharmacological study of the preparation was shown diuretic effect and it was no toxicity.On the basis of the study of optimal condition of extraction process was developed technology of preparation of drug formulation from Bergenia crassifolia by repercolation method and their quality assessment.
The result of the study shows possibility of development of technological instruction for the preparation and project of the standart for their quality control. It was found diuretic action of the preparation from Bergenia crassifolia and the minimal toxic dose was 1,25 g/kg.
Онош, 2002, (014) 2002.No2(014)
Activity of Bergenia crassifolia / Fritish /
( Судалгааны өгүүлэл )
Абстракт
Нийтлэлийн нээгдсэн тоо: 382
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