Introduction:
Gonadotropins are released under the control of gonadotropin-releasing hormone (GnRH) from the arcuate nucleus and preoptic area of the hypothalamus. The gonads — testes and ovaries — are the primary target organs for LH and FSH. The gonadotropins affect multiple cell types and elicit multiple responses from the target organs. As a simplified generalization, LH stimulates the Leydig cells of the testes and the theca cells of the ovaries to produce testosterone (and indirectly estradiol), while FSH stimulates the spermatogenic tissue of the testes and the granulosa cells of ovarian follicles. Reproductive aging is endocrinologically characterized by a progressive rise in serum FSH levels associated with a decrease in serum estradiol (E2) and testosterone (T) levels. The rise in FSH is associated with reduced levels of sex steroid and peptide negative feedback regulators of FSH secretion.
The aim of study is:
determination of serum FSH level changes in relation to aging and sex.
Materials and Methods:
In this study were involved 169 healthy Mongolian adults aged above 45 years old. Subjects were randomly selected and undergone physical examination by geriatrician. People, who are receiving hormone replacement therapy, using inproper use of alcohol, injured and had surgery were excluded from our surgery. Blood samples were collected in the early morning (8.30–10.30 AM) after an all night fast and plasma was separated immediately by centrifugation; then sera obtained were stored at -20°C until assayed by ELISA kit from United Biotech CoLTD, USA, which sensitivity is 1mIU/ml. Statistical analyses have been performed by statistical software SPSS 16, using ANOVA, Pearson correlation, T-test.
Result:
Mean level of FSH for both sexes was 21.19±16.2 mIU/ml, which is in comparison with males (12.33±10.58 mIU/ml) it was comparatively higher (p 0.001) in women (29.61±16.15 mIU/ml). FSH has no correlation with aging in man (r=0.084, p>0.05), but in women it was stronger correlation (r=0.203, p 0.05). in 51-60 years age group FSH was increased by 56%, in 61-65 years group by 91%, in 66-70 years group it was increased 100% in comparison with until 50 years age group. In older age (above 70 years) it decreased to 70% from reached concentration. ANOVA analysis has not showed significant difference between age groups.
Conclusions:
Average mean of FSH in old age are: 29.61±16.15 mIU/ml in women and 12.33±10.58 mIU/ml in men. Correlation with aging was observed stronger in women than in man (r=0.203, p 0.05). FSH increases with aging until round 70 and decreases after 70 years old
