Монголын Анагаахын Сэтгүүлүүдийн Холбоо (МАСХ)
Mongolian Journal of Health Sciences, 2007, 1(4)
Analysis on 15 str markers in three regional mongolian populations
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TserenbatM.', YamomotoT.2, Katsumata Y.\\\\\\\\\\\\\\\\ Yoshimoto T.2, UchihiR.2, GanboldS.4, Purewdorj I.'

'School of Biomedicine, Health Sciencesllniversity of Mongolia

2Nagoya University, School of Medicine

^National Institute of Police Science

4National Center of Forensic Investigation

 
Абстракт

In forensic field, short tandem repeat (STR) markers are utilized globally for personal identification and kinship analysis using some commercially available kits, and databases. We constructed a database at 15 STR loci and calculated statistical probabilities, and also analyzed those data with published data and our own data phylogenetically and genetic statistically. The genetic differences of the allele frequency distributions for 15 STR loci among three regions of Mongolia were examined using multiplex amplification and typing system, "QIAGEN", to construct a genetic database in Mongolian population. Genotypes at 15 STR loci were analyzed in 600 individuals from the area of Ulaanbaatar, Ulaangom and Dalanzadgad. The allele frequency distributions were significantly different (p < 0.05) at from three to five loci among the three populations when compared pair wise using Genepop software. We constructed a neighbor-joining tree based on Nei's DA genetic distance using Nabafd and Mega 3 software. Accordingly, three regional Mongolian populations and four regional Japanese populations formed each one cluster separately, and Mongolians located closer to the other east and southeastern Asian populations than Japanese. We also performed Multi-dimensional Scaling analysis based on Fst genetic distances using Microsat and SPSS 12 software. In the result, the distributions were very similar to their geographical locations.

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