Дорно дахины уламжлалт анагаах ухаан, 2013, 2(5)
DIFFERENT EFFECTS OF POLAPREZINC AND ZINC CHLORIDE ON ZINC SUPPLEMENTATION IN ELDERLY BEDRIDDEN PATIENTS RECEIVING ENTERAL NUTRITION
( Тойм өгүүлэл )
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Абстракт
Introduction Zinc,an essential trace element
in the human body,is known to serve as the active
center of approxi-mately 300 enzymes.1 Zinc
deficiency causes various pathological conditions
such as growth retardation,immunodeficiency,and
neurological degeneration.Zinc deficiency is typically
the result of inadequate dietary intake of zinc,the
recommended dietary allow-ance for zinc has been
presented for healthy individ-uals in the“Dietary
Reference Intakes for Japanese,2005”by the Japanese
Ministry of Health,Labor,and Welfare.2 However,we
have recently reported that zinc deficiency is common
in elderly bedridden patients receiving long-term
enteral nutrition based on the recommended dietary
allowance,and that zinc deficiency may be associated
with increased suscepti-bility to infections in those
patients.3.4 On the basis of the findings,we have
proposed that zinc preparations should be added to
the standard enteral formulas to prevent infectious
diseases in elderly bedridden patients.Ordinarily,zinc
preparations used for zinc therapy are inorganic
salts(e.g.,zinc sulphate,zinc picolinate,or zinc
chloride)and organic compounds(e.g.,polaprezinc or
zinc gluconate).Previous studies have revealed the
different activities for zinc therapy between inorganic
salts and organic compounds.5.6
Ном зүй
1. Yanagisawa H, Nodera M. Zinc physiology and clinical
practice. Biomed Res Trace Elements 2007; 18: 3-9.
2. SasakiS. Dietary reference intakes (DRIs)in Japan. Asia Pac
J Clin Nutr 2008; 17: 420-444.
3. Ukita T,Oidov B,Kawada E,at al. Serum zincdeficiency
increases susceptibility to infection in older patients who
have long-term hospitalizations. Biomed Res Trace Elements
2008; 19 : 260-264.
4. Fujita K,Narahara N,Morita T,et al. Iszincdeficiencya risk
factor of infection in elderly? A pilot study. Kita- kanto
Med J 2002; 52: 13-15.
5. Nagamine T, Takagi H, Takayama H, et al. Preliminary
studyofcombination therapywith interferon-α and zincin
chronic hepatitis C patients with genotype 1b. Biol Trace
Element Res 2000; 75: 53-63.
6. Seiki M, Aita H, Mera Y, et al. The gastric mucosal
adhesivenes of Z-103 in rats with chronic ulcer［in
Japanese］. Nippon Yakurigaku Zas hi 1992; 99 : 255-
263.
7. Matsukura T,Tanaka H. Applicability of zinc complex of
L-carnosineformedical use. Biochemistry 2000; 65: 817- 823.
8. NPUAP (National Pres ure Ulcer Advisory Panel) staging
system, 2007. ht p : //www.npuap.org/pr2.htm
9. NPUAP (National Pres ure Ulcer Advisory Panel) PUSH (Pres
ure Ulcer Scale for Healing) Tool Version 3.0.http : //
www.npuap.org/push3-0.htm
10. King JC, Shames DM, Woodhouse LR. Zinc homeostasis in
humans. J Nutr 2000; 130: 1360S-1366S.
11. Krebs NF, Hambidge KM. Zinc metabolism and homeostasis:
the application of tracer techniques to human zinc
physiology. Biometals 2001; 14: 397-412.
12. Liuzzi JP, Bobo JA, Lichten LA, et al. Responsive transporter
genes within the murine intestinal-pancreatic axis
from a basisofzinchomeostasis. ProcNatl Acad Sci USA
2004; 101: 14355-14360.
13. Nishimura Y, Matsukura T. Zinc uptake enhancing efect ofLcarnosine
［in Japanese］. Biomed ResTrace Elements 2000;
11: 347-348.
14. Sandstead HH. Trace element interactions. J Lab Clin Med
1981; 98: 457-462.
15. Mil s CF. Dietary interactions involving the trace ele- ments.
Annu Rev Nutr 1985; 5: 173-193.
16. Oestreicher P,Cousins RJ. Copper and zincabsorption in the
rat: mechanism of mutual antagonism. J Nutr 1985; 115:
159-166.
17. Cousins RJ, Dunn MA, Leinart AS, et al. Coordinate
regulation of zinc metabolism and metal othionein gene
expres ion in rats. Am J Physiol 1986; 251: E688-E694.
18. Yanagisawa H. Zinc deficiency and clinical practice. JMAJ
2004; 47: 359-364.
19. Tomita H. Taste disorder and diet ［in Japanese］.
Tokyo: Kodansha Ltd, 2002.
20. Keelaghan E, Margolis D, Zhan M, et al. Prevalence of
pres ure ulcers on hospital admis ion among nursing home
residents transfer ed to thehospital. Wound Repair Regen
2008; 16: 331-336.
21. Reddy M, Gil SS, Rochon PA. Preventing pres ure ulcers:
a systematic review. JAMA 2006; 296: 974-984.
22. Al man RM, Goode PS, Burst N, et al. Pres ure ulcers,
hospital complications, and disease severity: impact on
hospital costs and length ofstay. Adv Wound Care1999 ;
12: 22-30.
23. Braden B,Bergstrom N. A conceptual schema forthestudy
oftheetiologyofpres urescores. Rehabil Nurs1987; 12: 8-12.
24. Baumgarten M, Margolis DJ, Localio AR, et al. Pres ure
ulcers among elderly patients early in the hospital stay. J
Gerontol A Biol Sci Med Sci 2006; 61: 749-754.
25. Horn SD, Bender SA, Ferguson ML, et al. The National
Pres ure Ulcer Long-Term Care Study: pres ure ulcer
development in long-term careresidents. J Am Geriatr Soc
2004; 52: 359-67.
26. Schol D, Langkamp-Henken B. Nutrient recommendations
for wound healing. J Intraven Nurs 2001; 24: 124- 132.
27. GrayM. Does oral zincsupplementation promotehealing of
chronic wounds? J Wound Ostomy Continence Nurs 2003;
30: 295-299.
28. Tenaud I,Sainte-MarieI,Jumbou O,et al. In vitro modulation
of keratinocyte wound healing integrins by zinc,
copper and manganese. Br J Dermatol 1999 ; 140: 26-34.
29. Todorovic V. Food and wounds: nutritional factors in wound
formation and healing. Br J Community Nurs 2002; 7:
43S
practice. Biomed Res Trace Elements 2007; 18: 3-9.
2. SasakiS. Dietary reference intakes (DRIs)in Japan. Asia Pac
J Clin Nutr 2008; 17: 420-444.
3. Ukita T,Oidov B,Kawada E,at al. Serum zincdeficiency
increases susceptibility to infection in older patients who
have long-term hospitalizations. Biomed Res Trace Elements
2008; 19 : 260-264.
4. Fujita K,Narahara N,Morita T,et al. Iszincdeficiencya risk
factor of infection in elderly? A pilot study. Kita- kanto
Med J 2002; 52: 13-15.
5. Nagamine T, Takagi H, Takayama H, et al. Preliminary
studyofcombination therapywith interferon-α and zincin
chronic hepatitis C patients with genotype 1b. Biol Trace
Element Res 2000; 75: 53-63.
6. Seiki M, Aita H, Mera Y, et al. The gastric mucosal
adhesivenes of Z-103 in rats with chronic ulcer［in
Japanese］. Nippon Yakurigaku Zas hi 1992; 99 : 255-
263.
7. Matsukura T,Tanaka H. Applicability of zinc complex of
L-carnosineformedical use. Biochemistry 2000; 65: 817- 823.
8. NPUAP (National Pres ure Ulcer Advisory Panel) staging
system, 2007. ht p : //www.npuap.org/pr2.htm
9. NPUAP (National Pres ure Ulcer Advisory Panel) PUSH (Pres
ure Ulcer Scale for Healing) Tool Version 3.0.http : //
www.npuap.org/push3-0.htm
10. King JC, Shames DM, Woodhouse LR. Zinc homeostasis in
humans. J Nutr 2000; 130: 1360S-1366S.
11. Krebs NF, Hambidge KM. Zinc metabolism and homeostasis:
the application of tracer techniques to human zinc
physiology. Biometals 2001; 14: 397-412.
12. Liuzzi JP, Bobo JA, Lichten LA, et al. Responsive transporter
genes within the murine intestinal-pancreatic axis
from a basisofzinchomeostasis. ProcNatl Acad Sci USA
2004; 101: 14355-14360.
13. Nishimura Y, Matsukura T. Zinc uptake enhancing efect ofLcarnosine
［in Japanese］. Biomed ResTrace Elements 2000;
11: 347-348.
14. Sandstead HH. Trace element interactions. J Lab Clin Med
1981; 98: 457-462.
15. Mil s CF. Dietary interactions involving the trace ele- ments.
Annu Rev Nutr 1985; 5: 173-193.
16. Oestreicher P,Cousins RJ. Copper and zincabsorption in the
rat: mechanism of mutual antagonism. J Nutr 1985; 115:
159-166.
17. Cousins RJ, Dunn MA, Leinart AS, et al. Coordinate
regulation of zinc metabolism and metal othionein gene
expres ion in rats. Am J Physiol 1986; 251: E688-E694.
18. Yanagisawa H. Zinc deficiency and clinical practice. JMAJ
2004; 47: 359-364.
19. Tomita H. Taste disorder and diet ［in Japanese］.
Tokyo: Kodansha Ltd, 2002.
20. Keelaghan E, Margolis D, Zhan M, et al. Prevalence of
pres ure ulcers on hospital admis ion among nursing home
residents transfer ed to thehospital. Wound Repair Regen
2008; 16: 331-336.
21. Reddy M, Gil SS, Rochon PA. Preventing pres ure ulcers:
a systematic review. JAMA 2006; 296: 974-984.
22. Al man RM, Goode PS, Burst N, et al. Pres ure ulcers,
hospital complications, and disease severity: impact on
hospital costs and length ofstay. Adv Wound Care1999 ;
12: 22-30.
23. Braden B,Bergstrom N. A conceptual schema forthestudy
oftheetiologyofpres urescores. Rehabil Nurs1987; 12: 8-12.
24. Baumgarten M, Margolis DJ, Localio AR, et al. Pres ure
ulcers among elderly patients early in the hospital stay. J
Gerontol A Biol Sci Med Sci 2006; 61: 749-754.
25. Horn SD, Bender SA, Ferguson ML, et al. The National
Pres ure Ulcer Long-Term Care Study: pres ure ulcer
development in long-term careresidents. J Am Geriatr Soc
2004; 52: 359-67.
26. Schol D, Langkamp-Henken B. Nutrient recommendations
for wound healing. J Intraven Nurs 2001; 24: 124- 132.
27. GrayM. Does oral zincsupplementation promotehealing of
chronic wounds? J Wound Ostomy Continence Nurs 2003;
30: 295-299.
28. Tenaud I,Sainte-MarieI,Jumbou O,et al. In vitro modulation
of keratinocyte wound healing integrins by zinc,
copper and manganese. Br J Dermatol 1999 ; 140: 26-34.
29. Todorovic V. Food and wounds: nutritional factors in wound
formation and healing. Br J Community Nurs 2002; 7:
43S
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