Дорно дахины уламжлалт анагаах ухаан, 2012, 2(3)
EFFECT OF SOME TRADITIONAL DRUG AND EXTERNAL THERAPIES ON CHANGES OF TNF LEVELS
( Тойм өгүүлэл )
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Абстракт
In this study, the effects of traditional drugs such as Zachun-13 and Sampilnorov on
serum levels of tumor necrosis factor (TNF) in mice model of arthritis induced by
formalin were examined. Moreover, the effect of traditional external therapies
including acupuncture, cauterization, pricking-cupping and massage on serum TNF
levels in patients with spinal disk herniation and long-term back muscle injury.
The study was done at the Research Center of Monos Medical University. Arthritis was
induced by formalin (0.5 g/kg) injection into the phalangeal joints of mice.
Sampilnorov and Zachun-13 were administered daily through oral tube at concentration
of 42.5 mg/kg and 14 mg/kg respectively. Serum levels of TNF were determined 1, 3
and 7 days after initiating the treatment. Acupuncture, cauterization, pricking-cupping
and massage were applied to patients once a day for 10 days.
After 1 day of treatment, serum levels of TNF was increased 3.09 fold by formalin
administration compare to control. This increase was reduced by Sampilnorov and
Zachun-13 1.19 and 1.8 fold respectively. Serum levels of TNF were increased 3.0 fold
in mice after 3 days of formalin administration. Sampilnorov and Zachun-13 reduced
these increases 1.17 and 1.93 fold respectively.
Serum levels of TNF increased 15.2 fold in patients with spinal disk herniation and
long-term back muscle injury compare to normal range of TNF level. Acupuncture,
cauterization, pricking-cupping and massage reduced increased serum levels of TNF in
patients 1.3 fold.
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