Дорно дахины уламжлалт анагаах ухаан, 2012, 2(3)
EFFECT OF VITAMIN C ON ARSENIC-INDUCED PATHOLOGY IN MICE
( Тойм өгүүлэл )
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Since ancient times, arsenic (As) compounds have been used to cure certain ailments.
However, it is a metalloid poison, with cancerous effects. The main cause of poisoning
from arsenic is usage of arsenic containing drinking water. According to WHO reports
the permitted maximum level of arsenic in drinking water is 0.01 ppm. According to
the study conducted in 57 sums (unit of the province) of 17 provinces of Mongolia,
arsenic levels in drinking water in some provinces especially Dornogobi, Dundgobi and
Gobisumber located in the southern part of Mongolia were higher than the allowed
level. Therefore, there is a great risk of arsenic related diseases among Mongolian
population.
The aim of this study is to induce arsenic related pathology in albino mice and examine
the effect of vitamin C on it. Six to eight week old 20 female Beijing breed mice
weighing 20-25 g were used. Experiments were carried out in vivarium (20±2℃) of
“Monos” medical university. Mice were fed with normal food for 28 days. Animals
were divided into 4 groups: group A or control group without arsenic treatment, group
B received arsenic at 1mg/kg per day, group C received arsenic at 30 mg/kg per day,
and group D received arsenic 30 mg/kg per day and vitamin C at dose of 20 mg/kg. The
arsenic and vitamin C were administered orally. After the treatment blood samples
were taken and analyzed for levels of АST, АLT, total protein, and glucose.
Hystopathological analysis of mice heart, liver, kidneys and lungs were also performed.
Weight losses in animals of all arsenic treated groups were observed. Arsenic increased
levels of АLT and decreased levels of АST, glucose and total protein in a dose
dependent manner. Hystopthological analysis revealed chronic inflammation,
dystrophy, and necrosis in the heart, liver, kidneys, and lungs in mice administered
arsenic. There were lesser change and injury detected in mice treated with vitamin C.
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