Дорно дахины уламжлалт анагаах ухаан, 2012, 2(3)
EFFECT OF ZOMOSHIN-6 DECOCTION AND CARAGANA JUBATA (PALL.) ON HAEMOSTATIC PARAMETERS AND LIPID PROFILES IN DIABETIC RATS
( Тойм өгүүлэл )
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Абстракт
Introduction: Diabetes mellitus is a complex, progressive disease, which is
accompanied by multiple cardiovascular complications. Oxidative stress is significantly
increased in diabetic patients and may lead to great haemostatic disturbances existing in
these patients. The major thrust was to review current literature on potential
interrelationships between haemostatic and metabolic abnormalities in diabetes
mellitus.
Zomoshin-6 decoction and Caragana jubata (Fabaceace) used in traditional Mongolian
medicine have been shown to have haemostatic and antiviral effects.
Objectives: The aim of this study was to examine the effect of Caragana jubata (Pall.)
Poir. and Zomoshin-6 decoction on haemostatic parameters and lipid profiles in
diabetic rats.
Methods: Diabetes was induced in rats by using alloxan at a dose of 150 mg/kg.
Control group received distilled water. Caragana jubata (Pall.) Poir and Zomoshin-6
were administered orally at doses of 2.0 g/kg and 0.2 g/kg respectively. Aspirin
(100mg/kg) was used for comparison as a standard medicine. All treatments were
performed daily for 3 weeks. Blood samples were obtained and analyzed for fibrinogen
levels, prothrombin time, triglycerides (TG) and plasma uric acid.
Results and conclusions: Levels of TG (p<0.05), glucose (p<0.03) and plasma uric
acid (p<0.02) were increased in rats administered alloxan compare to control and these
were significantly reduced by Caragana jubata and Zomoshin-6 treatments (Table 1).
Caragana jubata and Zomoshin-6 significantly reduced increases in fibrinogen
(p<0.05) level and prothrombin time induced by alloxan (Table 2).
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