Дорно дахины уламжлалт анагаах ухаан, 2012, 2(3)
STUDY OF SOME TRADITIONAL DRUGS BASED ON CALCITE PROCESSED BY TRADITIONAL TECHNOLOGY
( Тойм өгүүлэл )
Өгүүллийн PDF-ийг татах
Абстракт
In traditional Mongolian Medicine, materials derived from plants, animals, trees, and
minerals are processed by traditional technology to improve their effectiveness and
safety. One of mineral-based materials is calcite which is widely used in traditional
medicine.
Mineral contents of calcite: After processing by traditional technology (taming) with
enrichment, calcite turns to bright yellow, small soft microcrystals with bitter taste and
smell of milk. Moreover it obtains solubility in water.
Various macro- and microelements were determined in tamed calcite including Na, Mg,
K, Ca, S, Mn, and Fe. Ca takes the major part (64%) of the elements.
Crystal size determined by NANOPHOX (PCCS), GmbH, Sympatec apparatus were
115 nm and 124 nm depending on the traditional technology of processing.
Crystal structure of calcite in phase shifts was analyzed after burning it in +300º C,
+500 º C, +800 º C, +1200 º C, and +1400 º C by using Shimadzu XRD-7000 X-ray
diffractometer, HA-1001, and TTK-450 apparatus. CaCO3 content (84.23%) was higher
at +300º C and +500 º C, while CaC2 content (15.77%) was higher at +800 º C, +1200
º C, and +1400 º C.
Effects of calcite on acetic acid-induced gastric ulcer: Gastric ulcer induced by
acetic acid in rats was healed completely by tamed calcite within 21 days. Calcite
improves bone repair of experimental fracture in rats by increasing Ca and alkaline
phosphatase activities.
Effects of calcite containing drug Jonsh-5 on experimental femur fracture in
rabbits: Jonsh-5 is composed of 5 components including calcite, Cardius crispus,
Forsythia suspense, Terminalia Chebula, and Inula helenium. Jonsh-5 increased serum
level of alkaline phosphatase after 7 days of fracture. X-ray images showed that healing
process of the bone was significantly increased by Jonsh-5 compare to control and
Calcium D3-Nycomed treatment. These results were also proved by histological
analysis suggesting that Jonsh-5 may promote bone healing in rat model of fracture.
Safety of calcite containing drugs: Contents of macro- and microelements, moisture,
and substances extractable in water have been determined. Mineral and organic
impurities have also been evaluated in Jonsh-5. Bacterial impurity of the drug is within
the standard range. Moreover contents of heavy metals such as lead, cadmium, and
mercury meat the WHO permeated levels of toxic metals.
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