Department of Microbiology and Immunology

School ofBiomedicine, Health Sciences University of Mongolia

Specific mutations of the p53 tumor suppressor gene in hepatocellular carcinoma (HCC) have been reported from several parts of the world. To date the status of this gene has not been studied in HCC patients in Mongolia where HCC is one of the major cancers and the consequence of chronic viral hepatitis B and C. The most frequent mutation of the p53 gene in HCC is an AGG (arg) to AGT (ser) missense mutation at codon 249 of exon 7. We analyzed 17 cases of HCC from Mongolian patients for

p53 mutation. No mutation was detected in codon 249 as well as 248 codon. HBV virus was detected in 16 cases which means that HBV infections play major role in pathogenesis and development of HCC among Mongolian patients.

Судлаачдын бусад өгүүлэл

Сүүлд хийгдсэн