Hepatocellular carcinoma (HCC) is one of the most common malignances in Mongolia. HCC is a multiple process associated with changes in gene expression. The gene expression profiles have not been studied yet in HCC and it also holds to the other cancers in Mongolia. In this study we tried to use differential display (DD) method to examine differences in gene expression between normal and cancer samples. We compared cyclinDl. cyclinE, c-myc. Rb gene expressions between normal and cancer cell of HCC. Analysis of expression cyclin Dl. we revealed overexpression in 40% (6/1 5), overexpression ol cyclinE 46.6% (7/15) and significant overexpression c-myc in 60% (9/1 5) in tumorous cell of HCC .In contrast, from other genes, the tumor suppressor Rb gene was downexpressed 33.3% (5/15) in tumor cells of HCC.

Судлаачдын бусад өгүүлэл

Сүүлд хийгдсэн