The purpose of this study was to find widely available, inexpensive, and non-invasive parameters for early identification or prediction of the infants with hypoxic-ischemic encephalopathy (HIE) who will have a severe adverse outcome. One hundred ninety two full-term or near-term newborn infants with a diagnosis of HIT. were consecutively

admitted to the neonatal intensive care and pathology units and studied. Occurrence of seizures during the first 24 hour, cranial ultrasonograph} (US) findings within the first 5 days of life, and Denver developmental screening test II (DDS T II) at 6 months of age. were analyzed in relation to mortality and neurological status at 2 years of age. Of the 192 infants, 19 were lost to follow-up. 82 of the remaining 1 73 infants had a moderate and severe adverse outcome. Among the predictors of severe adverse outcome, occurrence of seizures was found to have a poor predictive accuracy. However. DDST II at 6 months of age. yielded a very high predictive accuracy (sensitivity 100%, specificity~95%). We conclude that DDST II at 6 months of age could be used in predicting severe neurological outcome in infants with HIE.

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