The research is based on an analysis of clinico-laboratory manifestations of endogenous intoxication in 103 patients with peritonitis after injury of the abdomen. Posttraumatic acute peritonitis(PTAP) was found to develop in 103 (20,6%) out of 500 patients with internal injuries of the abdominal organs and open wounds of the abdominal cavity. The concentration of middle sized proteins (MSP) change during the course of each type of acute peritonitis with a high probability of intoxication by previous components.The first days after surgical operation the dynamic exchange of the middle sized proteins and those previous components are similar. however the decrease in concentration of middle sized proteins occurs later than the decrease previous components. The concentration of MSP during peritonitis should be used an important criteria to early-detemine the

severity of endogenous intoxication, to examine the health status of patients and to develop further treatment strategy. Mongolian blood serum MSP average is at 0.248+0.03 units. No difference in values of varying gender, age and living location based on statistical value was proven.

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