Монголын Анагаахын Сэтгүүлүүдийн Холбоо (МАСХ)
Mongolian Journal of Health Sciences, 2008, 1(5)
Influence of Numrugt Banzdoo (Saussurea involucrata Kar et Kir.Sch.Bip) plant polysaccharide on the immune complement system
( Судалгааны өгүүлэл )

Banzaagaya M,1* Choijamts G,1 Batbayar N,2 Batsuren D,2 Radnaa N,2 Paulsen B3, Inngjerdingen K,3 Dash Ts4

1 Department of Pharmacology, Health Sciences University of Mongolia, Ulaanbaatar, Mongolia
2 Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences, Ulaanbaatar, Mongolia
3 Oslo University, 1068 Blindern, Oslo, Norway
4 Deparment of Biochemistry and Microbiology, Health Sciences University of Mongolia, Ulaanbaatar, Mongolia
 
Абстракт

Saussurea involucrata is a traditional Mongolian medicine used in the treatment of purlulent lung infections, lung fever and wound fever. The objective of this investigation was to study the influence of the acidic and neutral pectin obtained from Numrugt Banzdoo (Saussurea involucrata Kar e t Kir. Sch. Bip) on the complement consumption assay.Four preparations of neutral and acidic polysaccharides extracted from Numrugt Banzdoo were studied at six different concentrations ranging from 15.6-500 mg/ml. We investigated the ability of these extracts to inhibit hemolysis of human blood by sensitized sheep red blood cells (SRBC) by standard methodology. We conclude that all 4 preparation made from Numrugt Banzdoo are more active than Plantago major II ( acidity 50îÑ ICH50<15, acidity 100îÑ ICH50<15, neutral 50îÑ ICH50<15, neutral 100îÑ ICH50=23, Plantago major II ICH50=28). It is clear from the results in Table 2 that the ICH50 of 3 preparations (all but the neutral one) at 100îÑ is twice as active as than of Plantago major II . The preparation from Numrugt Banzdoo has a relatively small molecular weight and high yield. We consider that it is possible to use and introduce it into practice as an immune adjuvant and to use it against different kinds of inflammation alone or in combination with other preparations.

 


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