Department of Pathology and Forensic medicine, School of Bio-Medicine, Health Sciences University of Mongolia

The Institute of Pathology, The Hospital of Dueren, Germany

Colorectal carcinoma occurs at all ages but people aged 39-59 affected more frequently. It spreads much more among the population of Europe and North America. It has tendency of increasing among the population of Asia. Some researchers consider that heredity factor has inter affection with surrounding environment. Lately in our country number of people who are affected with colorectal cancer, it is connected with the analyze index of endoscopy and biopsy. In 2008-2009 we did a histological and immunohystochemical analyze in 45 biopsy and in 135 biopsy of control we used P53, Ki67, CDX2, CEA, CK20, CK7, CK18, CA125 marker. In our research 23 patients aged 30-89 were involved, 16(70%) of them were males and 7(30%) were females. For age 7 (30%) of them were 30-49, 6(26.1%) and 5(21.7%)-70-79. Sex proportion of males and females of colorectal cancer was 11:5, their mean age was 58.1±0.4. Seeing from the result of immunohistochemical analyze when we analyzed p53 marker on 16 case which was diagnosed as colorectal cancer, 7 adenoma in 25% revealed as negative 25% medium negative and in 50% it revealed strong positive in adenoma p53 marker medium positive activation was 28.5% strong positive

reaction revealed by 71.4%. Ki67 was in 25% strong positive or with 70% and revealed 11/16 medium positive activation. When we analyzed Ki67 marker in adenoma medium and strong positive condition occupied most of percentage. 88% of colorectal cancer was diagnosed as adenocarcinoma. Cases involved in research were diagnosed in the р53 marker stage or in the later period in G2 of cell or at medium secretion period. Among p53 marker of cancer 50% was medium strong positive, in 70%, Ki67 marker revealed medium positive it shows that toxicity of cancer as reveals with high speed Classic marker CK20 of colorectal cancer revealed in 75 as medium and strong positive reaction. It expresses that mostly primary cancer of heredity cause.

 

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