Department of Microbiology and Immunology,

Health Sciences University of Mongolia

auto-antibodies are most widely used diagnostic tools for diagnosis and differential diagnosis of systemic autoimmune diseases in clinical practice. In this cross-sectional study, 140 patients aged from 18-72 years old (51 males and 89 females) with confirmed immune disorder pathologies, including 82 patients with rheumatoid arthritis (RA), 40 patients with systemic lupus erythematosus (SLE) and 18 patients with psoriatic arthritis (PA) were enrolled. 181 subjects without legend and current clinical and laboratory findings of systemic diseases attended as the control group. Determination of serum RF-IgM and anti-dsDNA titer were performed in all attendants using ELISA (Magiwell INC. USA). Titer of

RF-IgM in range of 25-55IU/mL were found in 45.1% of patients with RA, in 25% of patients with SLE, in 38.9% of patients with PA and in 12.2% of healthy subjects, but higher titers (more than 55IU/mL) were found only in 45.1% of patients with RA while only 9.8% of patients with RA has demonstrated titers of RF-IgM in normal range (less tha 25IU/mL). Titers of anti-dsDNA with range of 25-40IU/mL were demonstrated in 24.4% of patients with RA, in 40% of patients with SLE, in 27.8% of patients with PA and only in 7.3% of healthy subjects. Only 9.8% of patients have shown titers of anti-dsDNA more than 40IU/mL, while 45% and 44.4% of patient with SLE and PA respectively and no healthy subject demonstrated a high level of the antibody. RF-IgM has shown higher sensitivity, specificity, PPV and NPV and better inter-rater agreement (k) for RA comparing with anti-dsDNA. However anti-dsDNA demonstrated higher sensitivity, specificity, PPV and NPV and better inter-rater agreement (k) for SLE and PA comparing with RF-IgM.. It was concluded that only high titer of RF-IgM for RA (k=0.74) and high titer of anti-dsDNA for SLE and PA (k=0.77 and

k=0.67 respectively) may have diagnostic significance.

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