Дэлхийд чимээгүй тахал гэж үзэж байгаа яс сийрэгжих өвчин болон элдэв төрлийн бэртэл гэмтлийн улмааас үүсч байгаа ясны хугарал нь аль ч улс оронд эрүүл мэндийн

болон нийгмийн тулгамдсан асуудлуудын нэг болоод байна. Энэ талаар уламжлалт анагаах ухааны арвин баялаг сангаас эрж ясанд сайн хэмээн бичиж тэмдэглэсэн хэсгүүдийг олон талаас шүүж үзээд Жонш-5 хэмээх шинэ найрлагыг бий болгож судаллаа.

Шинэлэг тал

Жонш-5 найрлагын ясны нөхөн төлжилтөнд үзүүлэх үйлдлийг анх удаа сорил туршилтын аргаар судлан тогтоосон.

Inroduction. Jonsh-5 has been used for treatment of bone fracture in traditional medicine. In this study, effect of Jonsh-5 on femoral fracture healing in rats and bone resorption markers of rat model of osteoporosis induced by retinoic acid were examined.

Methods. Sandard closed fracture was created using three-point device. Rats were given orally CaD3 Nycomed (standard medicine, 60 mg/day); and Jonsh-5 (100 mg/day). Serum levels of transforming growth factor (TGF)-β1 were determined by ELISA. Radiography was performed at 14 and 28 days post-fracture. Osteoporosis was induced by retinoic acid (70 mg/kg, 14 days) administration. Jonsh-5 (0.5 g/kg) and CalciD-Denk (1.16 g/kg) were administered orally. Blood levels of collagen type 1 cross-linked C-telopeptide (CTx) and receptor activator of nuclear factor kappa-B ligand (RANKL) were measured by ELISA.

Results. Radiography revealed significantly accelerated fracture healing in the Jonsh-5 treated rats. Serum levels of TGF-β1 significantly reduced by Jonsh-5 at 3, 14, and 28 days post-fracture. Jonsh-5 significantly reduced increases in СТх and RANKL induced by retinoic acid.

Conclusions. Jonsh-5 has a potent fracture healing property in rat model of femoral fracture. Calcite compound can be

beneficial for treatment of osteoporosis through enhancing osteoblast differentiation and bone formation.

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