ЭМШУИС-ийн Говь-Алтай салбар сургууль

ЭМШУИС

Background: Rheumatoid arthritis related autoantibodies were bind to collagen of the connective tissue and which formulated the immune complex. Circulating immune complex can be deposited in joint capsule and ligament forming the jelly like pathological protein which known as the “pannus”. There is still not explained yet whether the small joints have been distorted in rheumatoid arthritis rather than the movement of the big joint is limited to rotation and limited range of motion. Thereby the movement of the big joints have been pinched the capsule of synovial fluid and it lead to deterioration of the joint. There is lack of study related to the structure and vascularization of vertebra and joints as well as the changes which occurred in aging process. That is the main cause of conducting an investigation on this area.

Goal of the study The vertebral structure and the structural changes as in the rheumatoid arthritis of human and mice have been proposed to study. Material and methods of the study There were enrolled 32 fetus aged from 14.9-31.1 week, in both sexes. The morphometrical measurements such as the height, width and thickness of vertebral column particularly its cervical , thoracic and lumbar region were assessed in the study. After that the histological methods were used for evaluation in overall 360 slides. The size localized calculation and smoother methods were employed and the growing rate was relatively rhythmic and prevalence was normal. Overall 60 mice have been enrolled in the study and we have divided them into three groups. In the first group we have treated with ibuprofen, and in the second group with boigor 10 and the control group. Results

of the study We measured and defined the height , the width and the thickness during fetal development stage representing the 4th vertebral cervix, 6th vertebral thoracic and 3rd vertebral lumbalis when they were not formed completely. The size localized calculation and smoother methods were employed and the growing rate was relatively rhythmic and

prevalence was normal. Ibuprofen treatment in rheumatoid arthritis played a significant role on reducing the distortion of the main cartilage of vertebra. Also it ceased the pannus deposition, and intensified the regeneration of cartilage. However the treatment with boigor-10 also lead to the interruption of deposition and intensified the ossification process rather than the regeneration. That is the main differences which noticed in the treatment groups. Conlusion:

1. We measured and defined the height ,width and thickness during the fetal development stage representing the 4th vertebral cervix,6th vertebral thoracic and 3rd vertebral lumbalis when they were not formed completely. The size localized calculation and smoother methods were employed and the growing rate was relatively rhythmic and prevalence was normal.

2. Ibuprofen treatment in rheumatoid arthritis were reduced the distortion of the main cartilage of vertebra. Also it ceased the pannus deposition, and intensified the regeneration of the vertebral cartilage.

3. The treatment of boigor-10 were interrupted the deposition of pannus on joints and intensified the ossification process of the vertebral cartilage.

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