Монголын Уламжлалт Анагаах Ухаан, 2013, 2(2)
Туршилтын амьтанд CCL4-өөр үүсгэсэн элэгний эмгэг загварт адууны мах, ямааны махны үзүүлэх нөлөөг улирлаас хамааруулан судалсан дүн
( Судалгааны өгүүлэл )
1Эрүүл Мэндийн Шинжлэх Ухааны Сургууль, Уламжлалт Анагаахын Сургууль,
2Уламжлалт Анагаахын Шинжлэх Ухаан, Технологи, Үйлдвэрлэлийн Корпораци
Абстракт
Background: Diet therapy is based on body constitution, disease conditions and seasonal
influences in traditional medicine. Traditional principles of disease treatment and prevention
with diet can be combined with conventional medical practices and may lead to a possibility
of developing new treatment and preventive strategies.
In traditional medicine, food and beverages are generally classified according to their quality
into hot and cold. Food and beverage with hot quality is used to treat diseases with cold quality
whereas food and beverage with cold quality is used to treat diseases with hot quality.
Objectives: In order to study the effects of interconnected factors of diet and season
on some pathological changes of organ systems, we examined the effects of horse meat
which has hot quality and goat meat which has cold quality on rat models of acute hepatitis
induced by CCL4 in spring and autumn respectively.
Materials and methods: CCL4 (200 mg/kg) was administered percutaneously to induce
acute hepatitis in rats. Horse and goat meat were given for 14 days before the CCL4
administration. Actovegin (2.8mg/kg) was used as a standard drug. Plasma levels of alanine
aminotransferase, aspartate aminotransferase were determined. Histological analysis of liver
tissues was performed.
Results: Results of our study show that goat meat which has cold quality is more
effective in autumn when a rise of bile element is occurred, and horse meat which has a
cold quality is more effective in spring when phlegm element rises.
More decreases in blood plasma levels of alanine aminotransferase and aspartate
aminotransferase were observed in acute hepatitis models of rats treated with horse and
goat meat in spring. These results are consistent with the theory of traditional medicine
that activities of vital and vessel organs are influenced by seasonal changes, as well as
accumulation, rise, and pacification processes of wind, bile, and phlegm elements. Thus the
results can further explain the traditional concept that liver function is decreased in autumn
when bile element rises and increased in spring when phlegm element rises.
Results of “goat meat + autumn” and “horse meat + spring” versions of treatment were
also showed by histological analysis which revealed a repair of classic lobular structure, more
recognizable liver cells, thickening of chromatin strands of hepatocytes, reduction in fatty
changes, increase in number of binucleated hepatocytes, and improvement in proliferative
processes in the liver.
Conclusions: The “spring + horse meat” and “autumn + goat meat” versions of
treatments more effectively decrease cytolysis during acute hepatocellular necrosis in animals
administered CCL4.
Нийтлэлийн нээгдсэн тоо: 2
