Шинэ Анагаах Ухаан Дээд Сургууль, Инновацийн төв
Background: Diabetes mellitus is a chronic metabolic disorder resulting from insulin deficiency, characterized by hyperglycemia, altered metabolism of carbohydrates, protein and lipids, and oxidative stress is increased, a situation that favors atherothrombotic processes, thrombogenesis, and endothelial dysfunction.
This work aimed at screening pellet of artichoke (Cynara scolymus L.) for its antiplatelet effect of in alloxan-induced diabetic rabbits.
Methods: The research was conducted at the Innovation center of “New medicine” Institute and in biochemical Laboratory of “Khuljborjigon” Clinic. The total number of rabbits used was 18. Male Shinshila rabbits, weighting 1.8–2.8 kg, were rendered diabetic with an injection of 100 mg/kg alloxan monohydrate into a marginal ear vein.
Results: Third day after injection of alloxan, untreated diabetic animals had the increased intensity of the protrombine time 15.46%, in comparison to normoglycemic animals.
Treatment with Artichoke pellet reduced of protrombine time by 21.3% in comparison with to animals that were made diabetic but not treated. By day 7, this value had decreased by about Alloxan-induced diabetic rabbits administered with Artichoke pellet showed 18.9% (p<0.001) decline in the protrombine time level on 3 and 14 day, respectively. They can also improve the condition of diabetes as indicated by parameters like trombone time, fibrinogen and active tromboplastine time.
Conclusion: In conclusion, Artichoke pellet exhibited significant antiplatelet effect in alloxan-induced diabetic rabbits.
