1Уламжлалт Анагаахын Шинжлэх Ухаан, Технологи, Үйлдвэрлэлийн корпораци, 2Эрүүл Мэндийн Шинжлэх Ухааны Их сургууль
Background: Garidi-5, a traditional medicine composed of 5 herbs including Terminalia chebula Retz., Aconitum Kusnezoffii Reichb., Acorus calamus L., Saussurea lappa L., and musk of Moschus moschiferus, has been used in traditional Mongolian medicine as an analgesic and antibacterial medicine. The present work was undertaken to evaluate the traditional drug Garidi-5 for its anti-inflammatory activity.
Methods: Rats in groups of five each were treated with vehicle, Garidi-5 (20, 80 and 200 mg/kg, p.o.) and Indometacin (10 mg/kg) one hour prior to Carrageenan injection. 0.1 ml of 1% Carrageenan was injected into the subplantar tissue of left hind paw of each rat. Swelling of carrageenan injected foot was measured at 0, 0.5, 2, 4 h using Plethysmometer (UGO Basile, Italy)). The right hind paw was injected with 0.1 ml of vehicle.
Results: The Garidi-5 (20, 80 and 200 mg/kg) significantly (P < 0.01) inhibited carrageenan induced rat paw edema as compared to control group. Maximum inhibition of paw edema was observed with Garidi-5 (80 and 200 mg/kg) at 4 h when compared to the control group.
In assay data, the TNF-α, IL-1β, IL-6 and IL-10 secretion in serum were highly elevated by carrageenan induction but administration of Garidi-5 significantly reduced serum secretion of inflammatory mediators as compared to vehicle group.
Conclusion: In conclusion, these results suggested that Mongolian traditional drug Garidi-5 anti-inflammatory effects.
