Монголын анагаах ухаан, 2015, 1(171)
Эмнэлгийн нано-бүтээгдэхүүний хоруу чанарыг in vitro орчинд судалсан дүн
( Судалгааны өгүүлэл )
Нийгмийн эрүүл мэндийн хүрээлэн
Абстракт
Background
Nano is a key technology to bring accelerated development in science, economy and business in 21st century. Besides lots of advantages contained in nanoproducts, cytotoxic effects on human and environment may occur due to their extreme small size and large surface area and it promotes chemical reaction and activates reactive oxygen species in the cell. In the last few decades, human and environment exposure of nanomaterials have been increasing, but research papers related to nanomaterial toxicity have been poor.
Goal
Determination of nanomaterial toxicity in medical application
Materials and Methods
Totally 21 nanomaterials collected in this study including imported nano-medicines, disinfectant spray, cleaning solution and experimental nanomaterial produced in Mongolia. The particle sizes of nanomaterialswere determined by Cross correlation analysis and X-Ray diffraction analysis, and mutagenicity was determined by Ames test.
Results
The particle sizes of nanomaterials in 5 of 21 were measured at the range of 1 – 100nm and 5 of 21 nanomaterials were determined as mutagenic by Ames test.
Conclusion
Ingredients and production methods can be one of causes of nanomaterial toxicity. Therefore, more specific methods are needed to reveal cytotoxicity of nanomaterials in the future.
Key words: Nanomaterial, nanoparticle, Ames test, Cross correlation analysis, X-Ray Diffraction analysis
Pp. 9-12, Table 1, Figures 2, References 11
Нийтлэлийн нээгдсэн тоо: 18
