Background

The overindulging alcohol leads to the structural changes in neurons of the brain, and to damages of the brain cognitive processes.

Goal

To determine the neuroprotective effect of complex herbal medicine «Sedaphyte» on ethanol induced experimental animal model.

Methods

We determined an abilities of avoid the inactive - unconditional reflex of rats on ethanol induced experimental model in dose 40% ethanol 9 ml/кg during 45 days per os. We were measured the quantity of malondialdehyde (MDA) and the activity of catalyze in brain tissue and analyzed the histology of brain tissue. The water infusion of complex herbal medicine «Sedaphyte» used in dose 1,0 ml/100g, also in comparison group was used Pyracetam in dose 200 mg/kg

Results

The complex herbal medicine «Sedaphyte» preserved the inactive - unconditional reflex of rats on chronically administrated ethanol in the form of keep in the dark chamber period was enhanced in 67 - 70% after 24 hours and in 44, 3 - 66, 8% after 7 days in comparison with control group. Also “Sedaphute” was decreased the amount of dark hyperchromic cell in hippocampus of rats brain on ethanol - induced alcoholic intoxication in 40%, the concentration of MDA in 52% and enhanced the catalyse activity in 30% in comparison with control group.

Conclusion. Our studies were shown that the complex herbal medicine “Sedaphyte” has neuroprotective effect in the experimental alcoholic intoxication. The principal mechanism of this pharmacological neuroprotective action is connected with the inhibition on lipid peroxidation and stimulatation on the antioxidant system of complex herbal medicine “Sedaphyte”.

Key words: alcoholic intoxication, activity of catalase, inactive - unconditional reflex, malondialdehyde, Sedaphyte.

Pp. 110-114, Tables 2, Figure 1, References 17

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