Dejidmaa B^1.2, Chimedragchaa Ch^1,2, Naran G³, Dagvatseren B¹,  Stepanovna TV¹

¹Traditional Medical Science Technology  and Production Corporation

²Health Sciences University of Mongolia

To study the anticoagulation and antithrombotic activities of the medicinal plant Caragana jubata Pall Poir on the experimental model of deep vein thrombosis induced in laboratory animals.

Thirty rats were used for the experiment and divided randomly and equally into 3 different groups: control group (saline), test group with C.Jubata and Warfarin treated group as a comparison.

The parameters such as Prothrombin time (PT) and the activated partial thromboplastin time (APTT) were measured by means of Quick’s one-stage assay and modified APTT assay respectively in the rats. Additionally, a thrombin activity test was estimatedin rats with PT assay using a hemagglutination analyzer.Thrombosis pathologic experimental model was induced.

Thrombi were recorded in all rats after experimentally induced thrombosis. As seen in histopathological assessment in the inferior vena cava of control group had formed thrombosis with the fibrin thread, erythrocytes and leucocytes. However in Caragana jubata pall poir (C.Jubata) group we noticed a little mass of fibrin and few leucocytes, and full of erythrocytes. Hence blood elements were few; formed thrombus was small and vessel cavity was free. Red thrombus formed in vein of Warfarin group animals has fibrin mass, occurring mostly in the wall, where as leucocytes were few, and erythrocytes were full. Fibrin thread was similar to the control group. As a result of research it was revealed that C.jubata prolonged Prothrombin time by 32.5%, thrombin time by 39.8%, where as fibrinogen amount decreased by 43.2%. It shows that C.Jubata has an anticoagulation activity while inhibiting blood coagulation and thinning blood.

C.Jubata medicinal plant  has anticoagulation activity and inhibits thrombosis.